The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression.

ASPERGILLOSIS is the second most imponant cause of fungal. infection after liver transplantaUon (LTx). with a mortality approaching 100%. In a previous study, we observed a 4% frequency of invasive aspergillosis in 101 consecutive LTx recipients. I Outcome depends on early treatment. however. the diagnosis of this disease is very difficult.2 The introduction of FK 506. allowed us to evaluate the impact of this new immunosuppressive agent on the incidence and outcome of aspergillosis following L Tx. and to compare this to a group of patients under traditional cyclosporine (Cy A) therapy.